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Jejunal pouch reconstruction but not preservation of duodenal passage after total gastrectomy reduces plasma cholecystokinin and pancreatic polypeptide long term in pigs.
- Source :
-
In vivo (Athens, Greece) [In Vivo] 2009 Jan-Feb; Vol. 23 (1), pp. 93-8. - Publication Year :
- 2009
-
Abstract
- Aim: The long-term effects of reconstructions of the gastrointestinal tract after gastrectomy on plasma levels of gastrointestinal hormones that contribute to food intake controls were evaluated.<br />Materials and Methods: Domestic pigs were randomly assigned to sham-surgery or total gastrectomy followed by reconstruction with oesophagojejunostomy on a Roux-en-Y loop (OJRY), jejunal interposition between the oesophagus and the duodenum (OJD), or an oesophagojejunostomy with a jejunal pouch reservoir (J-pouch) on a Roux-en-Y loop. Plasma levels of peptides were analysed by radioimmunoassay (RIA).<br />Results: Ten weeks after surgery, levels of cholecystokinin (CCK) and pancreatic polypeptide (PP) were significantly lowered (79.6% and 67.0%, respectively) in animals with a J-pouch, but not in sham-operated animals or animals with OJRY or OJD, as compared to preoperative levels. The levels of neuropeptide Y (NPY) and peptide YY (PYY) remained unchanged, irrespective of the mode of reconstruction.<br />Conclusion: J-pouch, but not preservation of duodenal passage after total gastrectomy, lowers levels of CCK and PP, peptides that reduce food intake.
- Subjects :
- Animals
Body Weight
Disease Models, Animal
Duodenum surgery
Eating
Esophagus surgery
Female
Jejunum surgery
Male
Neuropeptide Y blood
Nutritional Status
Peptide YY blood
Postgastrectomy Syndromes pathology
Swine
Anastomosis, Roux-en-Y
Cholecystokinin blood
Colonic Pouches
Pancreatic Polypeptide blood
Postgastrectomy Syndromes blood
Subjects
Details
- Language :
- English
- ISSN :
- 0258-851X
- Volume :
- 23
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- In vivo (Athens, Greece)
- Publication Type :
- Academic Journal
- Accession number :
- 19368131