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Neuropeptide Y and gamma-melanocyte stimulating hormone (gamma-MSH) share a common pressor mechanism of action.
- Source :
-
Endocrine [Endocrine] 2009 Jun; Vol. 35 (3), pp. 312-24. Date of Electronic Publication: 2009 Apr 11. - Publication Year :
- 2009
-
Abstract
- Central circuits known to regulate food intake and energy expenditure also affect central cardiovascular regulation. For example, both the melanocortin and neuropeptide Y (NPY) peptide families, known to regulate food intake, also produce central hypertensive effects. Members of both families share a similar C-terminal amino acid residue sequence, RF(Y) amide, a sequence distinct from that required for melanocortin receptor binding. A recently delineated family of RFamide receptors recognizes both of these C-terminal motifs. We now present evidence that an antagonist with Y1 and RFamide receptor activity, BIBO3304, will attenuate the central cardiovascular effects of both gamma-melanocyte stimulating hormone (gamma-MSH) and NPY. The use of synthetic melanocortin and NPY peptide analogs excluded an interaction with melanocortin or Y family receptors. We suggest that the anatomical convergence of NPY and melanocortin neurons on cardiovascular control centers may have pathophysiological implications through a common or similar RFamide receptor(s), much as they converge on other nuclei to coordinately control energy homeostasis.
- Subjects :
- Animals
Arginine analogs & derivatives
Arginine pharmacology
CHO Cells
Cells, Cultured
Cricetinae
Cricetulus
Energy Metabolism drug effects
Energy Metabolism physiology
Hormone Antagonists pharmacology
Humans
Male
Mice
Neuropeptide Y antagonists & inhibitors
Neuropeptide Y metabolism
Rats
Rats, Sprague-Dawley
Signal Transduction drug effects
Signal Transduction physiology
Vasomotor System drug effects
Vasomotor System metabolism
Vasomotor System physiology
gamma-MSH metabolism
Cardiovascular Physiological Phenomena drug effects
Neuropeptide Y physiology
gamma-MSH physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1355-008X
- Volume :
- 35
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Endocrine
- Publication Type :
- Academic Journal
- Accession number :
- 19363600
- Full Text :
- https://doi.org/10.1007/s12020-008-9141-3