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Neuropeptide Y and gamma-melanocyte stimulating hormone (gamma-MSH) share a common pressor mechanism of action.

Authors :
Gruber KA
Fan W
Akerberg H
Larhammar D
Chee MJ
Colmers WF
Cone RD
Source :
Endocrine [Endocrine] 2009 Jun; Vol. 35 (3), pp. 312-24. Date of Electronic Publication: 2009 Apr 11.
Publication Year :
2009

Abstract

Central circuits known to regulate food intake and energy expenditure also affect central cardiovascular regulation. For example, both the melanocortin and neuropeptide Y (NPY) peptide families, known to regulate food intake, also produce central hypertensive effects. Members of both families share a similar C-terminal amino acid residue sequence, RF(Y) amide, a sequence distinct from that required for melanocortin receptor binding. A recently delineated family of RFamide receptors recognizes both of these C-terminal motifs. We now present evidence that an antagonist with Y1 and RFamide receptor activity, BIBO3304, will attenuate the central cardiovascular effects of both gamma-melanocyte stimulating hormone (gamma-MSH) and NPY. The use of synthetic melanocortin and NPY peptide analogs excluded an interaction with melanocortin or Y family receptors. We suggest that the anatomical convergence of NPY and melanocortin neurons on cardiovascular control centers may have pathophysiological implications through a common or similar RFamide receptor(s), much as they converge on other nuclei to coordinately control energy homeostasis.

Details

Language :
English
ISSN :
1355-008X
Volume :
35
Issue :
3
Database :
MEDLINE
Journal :
Endocrine
Publication Type :
Academic Journal
Accession number :
19363600
Full Text :
https://doi.org/10.1007/s12020-008-9141-3