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[The antiphospholipid syndrome. The neurological complications and the therapeutic possibilities].
- Source :
-
Deutsche medizinische Wochenschrift (1946) [Dtsch Med Wochenschr] 1991 Nov 22; Vol. 116 (47), pp. 1794-6. - Publication Year :
- 1991
-
Abstract
- For several months a 23-year-old woman had been suffering from increasingly frequent attacks of bilateral amaurosis fugax. They affected only individual segments of a monocular visual field and finally occurred several times daily. Physical and cardiological examinations as well as echocardiography were within normal limits. Laboratory tests revealed a slight increase in erythrocyte sedimentation rate and high titres of serum antibodies against phospholipids. Fundoscopy did not show any vascular changes. Because vasculitis--possibly as an expression of systemic lupus erythematodes--was suspected, high-dosage treatment with steroids was commenced, but failed to influence the visual disorder. While steroid dosage was gradually decreased, administration of acetylsalicylic acid (for three months 100 mg daily, then three times daily 100 mg) brought about complete disappearance of the visual signs. Their cause was probably a reversible platelet aggregation induced by antiphospholipid antibodies which, because of the physiological characteristics of the terminal retinal vascular bed brought about the isolated sign of recurrent amaurosis fugax.
- Subjects :
- Adult
Antibodies blood
Antiphospholipid Syndrome diagnosis
Antiphospholipid Syndrome drug therapy
Aspirin administration & dosage
Blindness diagnosis
Blindness drug therapy
Blindness etiology
Female
Humans
Nervous System Diseases diagnosis
Nervous System Diseases drug therapy
Phospholipids immunology
Recurrence
Remission Induction
Time Factors
Antiphospholipid Syndrome complications
Nervous System Diseases etiology
Subjects
Details
- Language :
- German
- ISSN :
- 0012-0472
- Volume :
- 116
- Issue :
- 47
- Database :
- MEDLINE
- Journal :
- Deutsche medizinische Wochenschrift (1946)
- Publication Type :
- Academic Journal
- Accession number :
- 1935673
- Full Text :
- https://doi.org/10.1055/s-2008-1063819