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cAMP-mediated regulation of CYP enzymes and its application in chemotherapy.
- Source :
-
Drug metabolism letters [Drug Metab Lett] 2007 Aug; Vol. 1 (3), pp. 176-8. - Publication Year :
- 2007
-
Abstract
- Certain anti-cancer prodrugs are subject to cytochrome P450 (CYP)-mediated metabolism and become more active. Because CYP activity may be regulated by phosphorylation via adenylyl cyclase/protein kinase A, selective adenylyl cyclase subtype activators may be utilized in future chemotherapy to regulate CYP activity as a switch in a tumor tissue-specific manner.
- Subjects :
- Adenylyl Cyclases metabolism
Animals
Antineoplastic Agents therapeutic use
Cyclic AMP metabolism
Cyclic AMP-Dependent Protein Kinases metabolism
Enzyme Activators pharmacology
Humans
Neoplasms drug therapy
Phosphorylation
Prodrugs therapeutic use
Antineoplastic Agents metabolism
Cytochrome P-450 Enzyme System metabolism
Prodrugs metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1874-0758
- Volume :
- 1
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Drug metabolism letters
- Publication Type :
- Academic Journal
- Accession number :
- 19356040
- Full Text :
- https://doi.org/10.2174/187231207781369744