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Luteolin inhibits adipogenic differentiation by regulating PPARgamma activation.
- Source :
-
BioFactors (Oxford, England) [Biofactors] 2009 Jul-Aug; Vol. 35 (4), pp. 373-9. - Publication Year :
- 2009
-
Abstract
- Luteolin (3',4',5,7-tetrahydroxyflavone), a flavonoid, has been known to possess antimutagenic, antitumorigenic, antioxidant, and anti-inflammatory properties. In this study, we investigated the role of luteolin in the regulation of adipogenic differentiation in 3T3-L1 preadipocytes. Luteolin inhibited intracellular triglyceride accumulation in a dose-dependent manner without cytotoxicity. Western blot and reverse transcription-polymerase chain reaction analyses showed that this inhibition was accompanied by attenuated expression of the adipogenic transcription factors: peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT/enhancer-binding protein alpha. Luteolin inhibited the PPARgamma transactivation stimulated by rosiglitazone, a synthetic agonist, in COS-7 cells and inhibited rosiglitazone-induced adipogenic differentiation in 3T3-L1 cells. These data suggest that luteolin exerts antiadipogenic effects by suppressing adipogenic transcription factors and by inhibiting the transactivation of PPARgamma.
Details
- Language :
- English
- ISSN :
- 1872-8081
- Volume :
- 35
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- BioFactors (Oxford, England)
- Publication Type :
- Academic Journal
- Accession number :
- 19353690
- Full Text :
- https://doi.org/10.1002/biof.38