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Biphasic activity of resveratrol on indomethacin-induced gastric ulcers.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2009 Mar 27; Vol. 381 (1), pp. 90-5. Date of Electronic Publication: 2009 Feb 12. - Publication Year :
- 2009
-
Abstract
- Resveratrol showed biphasic activity in indomethacin-induced gastric ulcerated mice. A protective effect at a lower dose (2 mg kg(-1)) and a contraindicative effect at a higher dose of Resveratrol (10 mg kg(-1)) were observed. This phenomenon was possibly controlled by a COX-1 and eNOS balance, which ultimately maintained angiogenesis in Resveratrol-treated pre-ulcerated mice. The lower dose of Resveratrol (2 mg kg(-1)) augmented eNOS expression without altering COX-1 expression, but, at a higher dose (10 mg kg(-1)), Resveratrol predominantly suppressed COX-1 expression, which significantly reduced both PGE2 synthesis and angiogenesis. Thus it ultimately resulted in delay healing of indomethacin-induced gastric ulcers. Hence, it could be concluded that COX-1 and eNOS acted as key regulatory factors switching the biphasic effects of Resveratrol in indomethacin-induced ulcerated mice.
- Subjects :
- Animals
Anti-Inflammatory Agents, Non-Steroidal toxicity
Contraindications
Indomethacin toxicity
Male
Mice
Resveratrol
Stomach Ulcer chemically induced
Stomach Ulcer enzymology
Stomach Ulcer pathology
Cyclooxygenase 1 metabolism
Membrane Proteins metabolism
Nitric Oxide Synthase Type III metabolism
Stilbenes administration & dosage
Stomach Ulcer prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2104
- Volume :
- 381
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 19351601
- Full Text :
- https://doi.org/10.1016/j.bbrc.2009.02.027