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Biflavonoids from Araucaria angustifolia protect against DNA UV-induced damage.
- Source :
-
Phytochemistry [Phytochemistry] 2009 Mar; Vol. 70 (5), pp. 615-20. Date of Electronic Publication: 2009 Apr 06. - Publication Year :
- 2009
-
Abstract
- Ultraviolet radiation is one of the most deleterious forms of radiation to terrestrial organisms and is involved in formation of mutagenic pyrimidine dimers and oxidized nucleotides. The biflavonoid fraction (BFF), extracted from needles of Araucaria angustifolia was capable of protecting calf thymus DNA from damage induced by UV radiation. This occurred through prevention of cyclobutane thymine dimer and 8-oxo-7,8-dihydro-2'-deoxyguanosine formation, this being quantified by high-performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS) in a multiple reaction monitoring mode (MRM) and by HPLC-coulometric detection, respectively.
Details
- Language :
- English
- ISSN :
- 1873-3700
- Volume :
- 70
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Phytochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 19349053
- Full Text :
- https://doi.org/10.1016/j.phytochem.2009.03.003