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Optimal starting time of acquisition and feasibility of complementary administration of nitroglycerin with intravenous beta-blocker in multislice computed tomography.
- Source :
-
Journal of computer assisted tomography [J Comput Assist Tomogr] 2009 Mar-Apr; Vol. 33 (2), pp. 193-8. - Publication Year :
- 2009
-
Abstract
- Objectives: We determined the optimal starting time of acquisition after sublingual nitroglycerin (NTG) administration and evaluated the effects on multislice computed tomographic (MSCT) images of a complementary administration of sublingual NTG with beta-blocker.<br />Methods: Sixty patients who underwent MSCT coronary angiography (CA) were randomly divided into 2 groups as follows: 30 patients given an intravenous administration of beta-blocker (landiolol hydrochloride, mean dose of 0.032 mg/kg per minute; group B); and 30 patients given a coadministration of intravenous beta-blocker and sublingual NTG (0.3 mg; group N). Blood pressure and heart rate were recorded every 1 minute after NTG administration. In addition, the maximum diameters of the proximal and distal lesions in each coronary artery were measured, and the number of assessable segments was calculated.<br />Results: Blood pressure significantly decreased and heart rate significantly increased 4 minutes after NTG administration. The number of assessable segments was significantly greater in group N than in group B. The maximum diameters of the distal lesions of the left anterior descending and left circumflex arteries and both proximal and distal lesions of the right coronary artery were significantly larger in group N than in group B.<br />Conclusions: It is advisable to obtain MSCT images after sublingual NTG administration because nitrates are always given during conventional CA and may prevent beta-blocker-induced coronary spasm. The optimal starting time for MSCT CA is approximately 3 minutes after sublingual NTG administration.
- Subjects :
- Administration, Sublingual
Adrenergic beta-Antagonists adverse effects
Aged
Blood Pressure drug effects
Coronary Stenosis chemically induced
Coronary Stenosis prevention & control
Drug Administration Schedule
Drug Therapy, Combination
Feasibility Studies
Female
Heart Rate drug effects
Humans
Injections, Intravenous
Male
Time Factors
Vasodilator Agents administration & dosage
Adrenergic beta-Antagonists administration & dosage
Coronary Angiography methods
Nitroglycerin administration & dosage
Tomography, X-Ray Computed methods
Subjects
Details
- Language :
- English
- ISSN :
- 1532-3145
- Volume :
- 33
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of computer assisted tomography
- Publication Type :
- Academic Journal
- Accession number :
- 19346844
- Full Text :
- https://doi.org/10.1097/RCT.0b013e31817f455a