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Impact of laparoscopic cystectomy on ovarian reserve: serial changes of serum anti-Müllerian hormone levels.

Authors :
Chang HJ
Han SH
Lee JR
Jee BC
Lee BI
Suh CS
Kim SH
Source :
Fertility and sterility [Fertil Steril] 2010 Jun; Vol. 94 (1), pp. 343-9. Date of Electronic Publication: 2009 Apr 05.
Publication Year :
2010

Abstract

Objective: To evaluate the ovarian reserve changes after laparoscopic cystectomy, we prospectively evaluated pre- and postoperative serum anti-Müllerian hormone (AMH) level, and ovarian volumes.<br />Design: Prospective longitudinal study.<br />Setting: University Hospital.<br />Patient(s): Twenty women with benign ovarian masses participated; endometrioma [13], mature teratoma [6], and mucinous cystadenoma [1]. Seven patients had bilateral ovarian masses.<br />Intervention(s): All patients had undergone laparoscopic ovarian cystectomy. Serum AMH levels were serially measured: preoperative, 1 week, 1 month, and 3 months after operation. Volumes of total ovary and ovarian mass were measured by 3D ultrasonography before operation.<br />Main Outcome Measure(s): Postoperative serum AMH level and ovarian volume.<br />Result(s): Median AMH level was 2.23 ng/mL (95% confidence interval [CI] 1.35-3.41 ng/mL) before operation, but reduced to 0.67 ng/mL (95% CI 0.44-1.70 ng/mL) at the first week postoperatively and then increased to 1.14 ng/mL (95% CI 0.79-2.36 ng/mL) in the first month and 1.50 ng/mL (95% CI 0.58-3.26 ng/mL) in the third month. The serum AMH level after 3 months postoperatively was recovered to about 65% of the preoperative level. The serum AMH level at postoperative 1 week was more decreased in endometrioma compared with nonendometrioma (33.9% vs. 69.2% of preoperative level), and in bilateral group compared with unilateral group (16.9% vs. 62.9%).<br />Conclusion(s): This study suggests that ovarian reserve could be reduced after laparoscopic cystectomy; however, it could be restored thereafter up to 3 months postoperative in reproductive women.<br /> (Copyright (c) 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1556-5653
Volume :
94
Issue :
1
Database :
MEDLINE
Journal :
Fertility and sterility
Publication Type :
Academic Journal
Accession number :
19345350
Full Text :
https://doi.org/10.1016/j.fertnstert.2009.02.022