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Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3).
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 May 01; Vol. 19 (9), pp. 2514-8. Date of Electronic Publication: 2009 Mar 14. - Publication Year :
- 2009
-
Abstract
- A series of amiloride derivatives modified at the 5-position of the pyrazine ring were evaluated as inhibitors of acid-sensing ion channel-3 (ASIC3), a novel target for the treatment of chronic pain.
- Subjects :
- Acid Sensing Ion Channels
Acidosis
Amiloride chemistry
Amines chemistry
Animals
Drug Design
Electrophysiology
Inhibitory Concentration 50
Male
Models, Chemical
Pyrazines chemistry
Rats
Rats, Sprague-Dawley
Amiloride analogs & derivatives
Chemistry, Pharmaceutical methods
Nerve Tissue Proteins chemistry
Pain drug therapy
Sodium Channels chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 19
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 19339181
- Full Text :
- https://doi.org/10.1016/j.bmcl.2009.03.029