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Diagnostic factors identified in 1020 women with two versus three or more recurrent pregnancy losses.
- Source :
-
Fertility and sterility [Fertil Steril] 2010 Mar 01; Vol. 93 (4), pp. 1234-43. Date of Electronic Publication: 2009 Mar 31. - Publication Year :
- 2010
-
Abstract
- Objective: To determine whether the frequency of abnormal results for evidence-based diagnostic tests differed among women with recurrent pregnancy loss (RPL) based on the number of prior losses (n = 2, 3, or > or =4) and to determine whether abnormal results for additional investigative diagnostic tests differed in prevalence among women with different numbers of pregnancy losses.<br />Design: Single-center, retrospective study.<br />Setting: Patients with RPL at a private practice.<br />Patient(s): One thousand twenty women who had two or more consecutive spontaneous pregnancy losses with the same partner.<br />Intervention(s): None.<br />Main Outcome Measure(s): Frequencies of abnormal results for evidence-based diagnostic tests considered definite or probable causes of RPL (karyotyping for parental chromosomal abnormalities; pelvic sonohysterography, hysterosalpingogram, or hysteroscopy for uterine anomalies; immunological tests for lupus anticoagulant and anticardiolipin antibodies; thrombophilic tests for the factor V Leiden mutation; and blood tests for thyroid-stimulating hormone [TSH] and fasting blood glucose). We also measured the frequency of abnormal results for nine additional investigative tests in the same patients (antiphosphatidyl serine antibodies, microbial infection, midluteal P, PRL, functional protein C activity, functional protein S activity, antithrombin activity, fasting homocysteine and methylenetetrahydrofolate reductase polymorphisms, and factor II mutation).<br />Result(s): The prevalence of abnormal results for evidence-based and investigative diagnostic tests did not differ among women with different numbers of pregnancy losses.<br />Conclusion(s): Evaluation of all couples with two, three, or more consecutive miscarriages is recommended.<br /> (Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Abortion, Habitual genetics
Abortion, Habitual immunology
Abortion, Habitual pathology
Adult
Blood Glucose metabolism
Cohort Studies
Female
Humans
Karyotyping
Male
Middle Aged
Pregnancy
Retrospective Studies
Risk Factors
Thyrotropin blood
Abortion, Habitual diagnosis
Diagnostic Tests, Routine methods
Subjects
Details
- Language :
- English
- ISSN :
- 1556-5653
- Volume :
- 93
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Fertility and sterility
- Publication Type :
- Academic Journal
- Accession number :
- 19338986
- Full Text :
- https://doi.org/10.1016/j.fertnstert.2009.01.166