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Treatment with green tea extract attenuates secondary inflammatory response in an experimental model of spinal cord trauma.
- Source :
-
Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2009 Aug; Vol. 380 (2), pp. 179-92. Date of Electronic Publication: 2009 Apr 01. - Publication Year :
- 2009
-
Abstract
- In this study, we evaluated the effect of green tea extract (that was administered 25 mg/kg intraperitoneal at 1 and 6 h after injury) in experimental animal model of spinal cord injury. The spinal cord trauma was induced by the application of vascular clips to the dura via a four-level T5-T8 laminectomy. Spinal cord injury in mice resulted in severe trauma characterised by oedema, neutrophilic infiltration and apoptosis. Also, immunohistochemical examination demonstrated a marked increase in immune reactivity for nitrotyrosine. All parameters of inflammation were attenuated by green tea extract. The degree of spinal cord inflammation, nitrotyrosine, poli (ADP-ribosio) synthetase (PARS) and neutrophilic infiltration was markedly reduced. Green tea extract significantly ameliorated the recovery of limb function. Values shown are mean +/- SE mean of ten mice for each group. *p < 0.01 versus sham, degrees p < 0.01 versus spinal cord injury. Taken together, our results clearly demonstrate that green tea extract treatment ameliorates spinal cord injury oxidative stress.
- Subjects :
- Animals
Apoptosis drug effects
Disease Models, Animal
Edema drug therapy
Edema etiology
Immunohistochemistry
Inflammation etiology
Male
Mice
Neutrophil Infiltration drug effects
Oxidative Stress drug effects
Poly(ADP-ribose) Polymerases drug effects
Poly(ADP-ribose) Polymerases metabolism
Spinal Cord Injuries physiopathology
Time Factors
Tyrosine analogs & derivatives
Tyrosine metabolism
Inflammation drug therapy
Plant Extracts pharmacology
Spinal Cord Injuries drug therapy
Tea chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1432-1912
- Volume :
- 380
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Naunyn-Schmiedeberg's archives of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 19337722
- Full Text :
- https://doi.org/10.1007/s00210-009-0414-z