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Acute toxicity of a single gavage dose of fumonisin B1 in rabbits.
- Source :
-
Chemico-biological interactions [Chem Biol Interact] 2009 May 15; Vol. 179 (2-3), pp. 351-5. - Publication Year :
- 2009
-
Abstract
- The aim of this study was to determine the clinical, pathological and mycotoxicological effects of oral administration of fumonisin B1 (FB1) in rabbits. Eighteen rabbits were randomly assigned to two experimental groups: control group, 0 mg FB1; fumonisin group, 31.5 mg FB1/kg body weight, corresponding to about 630 mg FB1/kg diet. Fumonisin administered as a single oral dose to rabbits resulted in acute toxicity, significantly interfering with body and liver weight. Serum biochemical analysis revealed a significant increase of total protein, alkaline phosphatase (AP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT), urea and creatinine in the group receiving FB1 compared to control animals, a finding characterizing hepatic and renal injury in this group. Urinary protein concentrations were markedly elevated at 12, 24, 48 and 72 h after dosing, although visible pathological abnormalities were not observed, probably because of rapid repair of the damage. FB1 was detected in feces, with a maximum concentration at 24 h after administration, indicating that the enterohepatic circulation is important in rabbits. FB1 concentrations found in urine were low, with peak elimination at 12 h after intoxication. The highest FB1 concentrations were observed in feces compared to urine and liver, demonstrating that feces are the main routes of excretion.
- Subjects :
- Administration, Oral
Alanine Transaminase blood
Alkaline Phosphatase blood
Animals
Anorexia chemically induced
Aspartate Aminotransferases blood
Body Weight drug effects
Creatinine blood
Disease Models, Animal
Feces chemistry
Fumonisins pharmacokinetics
Lethargy chemically induced
Male
Organ Size drug effects
Rabbits
Tissue Distribution
Toxicity Tests, Acute
Urea blood
gamma-Glutamyltransferase blood
Fumonisins administration & dosage
Fumonisins toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7786
- Volume :
- 179
- Issue :
- 2-3
- Database :
- MEDLINE
- Journal :
- Chemico-biological interactions
- Publication Type :
- Academic Journal
- Accession number :
- 19330885
- Full Text :
- https://doi.org/10.1016/j.cbi.2009.01.005