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The 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) coadministered with DTPw-HBV/Hib and poliovirus vaccines: assessment of immunogenicity.
- Source :
-
The Pediatric infectious disease journal [Pediatr Infect Dis J] 2009 Apr; Vol. 28 (4 Suppl), pp. S89-96. - Publication Year :
- 2009
-
Abstract
- Background: Immunogenicity of the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D-conjugate vaccine (PHiD-CV) was evaluated when coadministered with DTPw-HBV/Hib and OPV at 6, 10, and 14 weeks of age in the Philippines, or with DTPw-HBV/Hib and IPV at 2, 4, and 6 months of age in Poland.<br />Methods: In this double-blind, controlled study (107007/NCT00344318), 400 Filipino and 406 Polish infants 6 to 12 weeks of age were randomized (3:1) to receive either PHiD-CV or the 7-valent pneumococcal conjugate vaccine (7vCRM). Immune responses were assessed 1 month post-dose III.<br />Results: Percentages of infants with anti-pneumococcal antibody concentrations >or=0.2 microg/mL (GSK's 22F-inhibition ELISA) were within the same range for both pneumococcal conjugate vaccine groups, with the exception of serotypes 6B and 23F for which lower percentages were observed in the PHiD-CV group in Poland. At least 98.2% of PHiD-CV vaccinees had antibody concentrations >or=0.2 microg/mL against pneumococcal serotypes 1, 5, and 7F. In both countries, anti-pneumococcal antibody geometric mean concentrations against serotypes 18C and 19F were higher in the PHiD-CV group than in the 7vCRM group. Antibody geometric mean concentrations for most of the other common serotypes were within the same range for both groups in the Philippines and were lower in the PHiD-CV group in Poland. Functional responses (opsonophagocytic activity [OPA]) were observed for all vaccine serotypes in both countries.<br />Conclusions: PHiD-CV was immunogenic against each of the 10 pneumococcal vaccine serotypes when coadministered with DTPw-HBV/Hib and poliovirus vaccines.
- Subjects :
- Double-Blind Method
Enzyme-Linked Immunosorbent Assay
Female
HL-60 Cells
Heptavalent Pneumococcal Conjugate Vaccine
Humans
Immunization Schedule
Infant
Male
Opsonin Proteins metabolism
Phagocytosis
Philippines
Pneumococcal Infections immunology
Pneumococcal Infections prevention & control
Poland
Streptococcus pneumoniae immunology
Treatment Outcome
Antibodies, Bacterial blood
Bacterial Proteins immunology
Carrier Proteins immunology
Diphtheria-Tetanus-Pertussis Vaccine administration & dosage
Diphtheria-Tetanus-Pertussis Vaccine immunology
Hepatitis B Vaccines administration & dosage
Hepatitis B Vaccines immunology
Immunoglobulin D immunology
Lipoproteins immunology
Pneumococcal Vaccines administration & dosage
Pneumococcal Vaccines adverse effects
Pneumococcal Vaccines immunology
Poliovirus Vaccines administration & dosage
Poliovirus Vaccines immunology
Streptococcus pneumoniae growth & development
Vaccines, Conjugate administration & dosage
Vaccines, Conjugate adverse effects
Vaccines, Conjugate immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0891-3668
- Volume :
- 28
- Issue :
- 4 Suppl
- Database :
- MEDLINE
- Journal :
- The Pediatric infectious disease journal
- Publication Type :
- Academic Journal
- Accession number :
- 19325451
- Full Text :
- https://doi.org/10.1097/INF.0b013e318199f901