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Antiplatelet therapies and the role of antiplatelet resistance in acute coronary syndrome.
- Source :
-
Thrombosis research [Thromb Res] 2009 May; Vol. 124 (1), pp. 6-13. Date of Electronic Publication: 2009 Mar 25. - Publication Year :
- 2009
-
Abstract
- Acute coronary syndrome is the number one killer in the industrialized world and, as such, continues to be one of the most well-studied disease states in all of medicine. Advancements in antiplatelet therapies for use in patients undergoing percutaneous coronary intervention have improved outcomes dramatically. However, a proportion of patients on long-term antiplatelet therapy continue to have cardiovascular events. Resistance to antiplatelet drugs may explain some of these events and this topic has become one of major interest and rapid evolution. This review describes the pathogenesis of acute coronary syndromes, outlines the evidence behind the use of the available antiplatelet agents, and examines the current data surrounding antiplatelet resistance.
- Subjects :
- Acute Coronary Syndrome blood
Acute Coronary Syndrome etiology
Angioplasty, Balloon, Coronary adverse effects
Angioplasty, Balloon, Coronary methods
Clinical Trials as Topic
Coronary Angiography adverse effects
Coronary Angiography methods
Humans
Models, Biological
Platelet Aggregation Inhibitors adverse effects
Acute Coronary Syndrome drug therapy
Drug Resistance
Platelet Aggregation Inhibitors therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1879-2472
- Volume :
- 124
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Thrombosis research
- Publication Type :
- Academic Journal
- Accession number :
- 19324398
- Full Text :
- https://doi.org/10.1016/j.thromres.2009.01.014