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Triple-negative breast cancers are increased in black women regardless of age or body mass index.
- Source :
-
Breast cancer research : BCR [Breast Cancer Res] 2009; Vol. 11 (2), pp. R18. Date of Electronic Publication: 2009 Mar 25. - Publication Year :
- 2009
-
Abstract
- Introduction: We investigated clinical and pathologic features of breast cancers (BC) in an unselected series of patients diagnosed in a tertiary care hospital serving a diverse population. We focused on triple-negative (Tneg) tumours (oestrogen receptor (ER), progesterone receptor (PR) and HER2 negative), which are associated with poor prognosis.<br />Methods: We identified female patients with invasive BC diagnosed between 1998 and 2006, with data available on tumor grade, stage, ER, PR and HER2 status, and patient age, body mass index (BMI) and self-identified racial/ethnic group. We determined associations between patient and tumour characteristics using contingency tables and multivariate logistic regression.<br />Results: 415 cases were identified. Patients were racially and ethnically diverse (born in 44 countries, 36% white, 43% black, 10% Hispanic and 11% other). 47% were obese (BMI > 30 kg/m2). 72% of tumours were ER+ and/or PR+, 20% were Tneg and 13% were HER2+. The odds of having a Tneg tumour were 3-fold higher (95% CI 1.6, 5.5; p = 0.0001) in black compared with white women. Tneg tumours were equally common in black women diagnosed before and after age 50 (31% vs 29%; p = NS), and who were obese and non-obese (29% vs 31%; p = NS). Considering all patients, as BMI increased, the proportion of Tneg tumours decreased (p = 0.08).<br />Conclusions: Black women of diverse background have 3-fold more Tneg tumours than non-black women, regardless of age and BMI. Other factors must determine tumour subtype. The higher prevalence of Tneg tumours in black women in all age and weight categories likely contributes to black women's unfavorable breast cancer prognosis.
- Subjects :
- Age Factors
Body Mass Index
Breast Neoplasms metabolism
Ethnicity
Female
Hispanic or Latino statistics & numerical data
Humans
Middle Aged
Neoplasm Staging
Prognosis
White People statistics & numerical data
Black or African American statistics & numerical data
Breast Neoplasms ethnology
Breast Neoplasms pathology
Receptor, ErbB-2 metabolism
Receptors, Estrogen metabolism
Receptors, Progesterone metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1465-542X
- Volume :
- 11
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Breast cancer research : BCR
- Publication Type :
- Academic Journal
- Accession number :
- 19320967
- Full Text :
- https://doi.org/10.1186/bcr2242