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[Bevacizumab and non-small cell lung cancer: a new step?].
- Source :
-
Revue des maladies respiratoires [Rev Mal Respir] 2009 Feb; Vol. 26 (2), pp. 125-38. - Publication Year :
- 2009
-
Abstract
- Inhibition of specific processes essential for tumour vascular development is one of the key strategies for the treatment of non- small cell lung cancer (NSCLC). Many agents target the Vascular Endothelial Growth Factor (VEGF) pathway, either by preventing VEGF receptor binding or inhibiting VEGF receptor signalling in endothelial cells. Bevacizumab is a monoclonal antibody specific for VEGF-A. Combination of bevacizumab with standard first-line chemotherapy in NSCLC leads to an improvement in response rates and progression-free survival compared to chemotherapy alone and a significant survival advantage with carboplatin- paclitaxel chemotherapy. Toxicity issues are of concern with the possible occurrence of hypertension and an increased risk of arterial thrombo-embolism. The occurrence of fatal pulmonary haemorrhage after necrosis of the primary tumour is a specific toxicity in NSCLC which requires appropriate selection of patients before treatment; excluding squamous cell carcinoma, haemorrhagic tumours and tumour invasion of major blood vessels. The use of bevacizumab combined with chemotherapy represent a first step in the development of antiangiogenic treatments in NSCLC, with the future possibility of using it in earlier stages of disease.
- Subjects :
- Antibodies, Monoclonal, Humanized
Antineoplastic Agents therapeutic use
Bevacizumab
Carcinoma, Non-Small-Cell Lung blood supply
Clinical Trials, Phase III as Topic
Drug Therapy, Combination
Humans
Lung Neoplasms blood supply
Vascular Endothelial Growth Factor A antagonists & inhibitors
Angiogenesis Inhibitors therapeutic use
Antibodies, Monoclonal therapeutic use
Carcinoma, Non-Small-Cell Lung drug therapy
Lung Neoplasms drug therapy
Subjects
Details
- Language :
- French
- ISSN :
- 0761-8425
- Volume :
- 26
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Revue des maladies respiratoires
- Publication Type :
- Academic Journal
- Accession number :
- 19319108
- Full Text :
- https://doi.org/10.1016/s0761-8425(09)71590-6