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The utility of 5-alpha reductase inhibitors in the prevention and diagnosis of prostate cancer.
- Source :
-
Current opinion in urology [Curr Opin Urol] 2009 May; Vol. 19 (3), pp. 238-42. - Publication Year :
- 2009
-
Abstract
- Purpose of Review: We examine the role of 5-alpha reductase inhibitors in prevention and diagnosis of prostate cancer, highlight the basic science supporting this role, and analyze the phase III clinical trials addressing the association between 5-alpha reductase inhibitor use and prostate cancer.<br />Recent Findings: To date, the Prostate Cancer Prevention trial (PCPT) is the only reported phase III randomized clinical trial to evaluate the role of 5-alpha reductase inhibitors in the prevention and treatment of prostate cancer. The original PCPT data revealed that finasteride reduced the risk of prostate cancer by approximately 25% in comparison with placebo. However, patients who received finasteride had a greater incidence of high-grade tumors, which prohibited acceptance of finasteride as a chemopreventive agent by most urologists. Recent updates of the PCPT findings confirmed that finasteride reduces the risk of clinically significant prostate cancer, including high-grade tumors, primarily due to its effects on improving the performance characteristics of prostate-specific antigen and prostate biopsy. There was no increase in high-grade prostate cancer. Rather, there was improved detection of high-grade prostate cancer due to decreased prostate volume.<br />Summary: Finasteride is a valuable chemopreventive tool because it reduces the risk of prostate cancer, including high-grade cancer, and enhances our ability to detect high-grade disease.
- Subjects :
- Azasteroids therapeutic use
Biopsy
Dutasteride
Enzyme Inhibitors adverse effects
Finasteride adverse effects
Finasteride therapeutic use
Humans
Male
Prostatic Neoplasms pathology
5-alpha Reductase Inhibitors
Enzyme Inhibitors therapeutic use
Prostatic Neoplasms diagnosis
Prostatic Neoplasms prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1473-6586
- Volume :
- 19
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Current opinion in urology
- Publication Type :
- Academic Journal
- Accession number :
- 19318950
- Full Text :
- https://doi.org/10.1097/MOU.0b013e328329eb29