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Serum fibroblast growth factor 21 is associated with adverse lipid profiles and gamma-glutamyltransferase but not insulin sensitivity in Chinese subjects.
- Source :
-
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2009 Jun; Vol. 94 (6), pp. 2151-6. Date of Electronic Publication: 2009 Mar 24. - Publication Year :
- 2009
-
Abstract
- Objective: Fibroblast growth factor (FGF) 21, a hormone primarily secreted by liver, has recently been shown to have beneficial effects on glucose and lipid metabolism and insulin sensitivity in animal models. This study investigated the association of serum FGF21 levels with insulin secretion and sensitivity, as well as circulating parameters of lipid metabolism and hepatic enzymes in Chinese subjects.<br />Design: Serum FGF21 levels were determined by ELISA in 134 normal glucose tolerance (NGT), 101 isolated-impaired fasting glucose, and 118 isolated-impaired glucose tolerance (I-IGT) Chinese subjects, and their association with parameters of adiposity, glucose, and lipid profiles, and levels of liver injury markers was studied. In a subgroup of this study, the hyperglycemic clamp technique was performed in 31 NGT, 17 isolated-impaired fasting glucose, and 15 I-IGT subjects to measure insulin secretion and sensitivity to test the associations with serum FGF21.<br />Results: The serum FGF21 levels in I-IGT were significantly higher than NGT subjects [164.6 pg/ml (89.7, 261.0) vs. 111.8 pg/ml (58.0, 198.9); P < 0.05], and correlated positively with several parameters of adiposity. Multiple stepwise regression analysis showed an independent association of serum FGF21 with serum triglycerides, total cholesterol, and gamma-glutamyltransferase (all P < 0.05). However, FGF21 did not correlate with insulin secretion and sensitivity, as measured by hyperglycemic clamp and a 75-g oral glucose tolerance test.<br />Conclusions: Serum levels of FGF21 are closely related to adiposity, lipid metabolism, and biomarkers of liver injury but not insulin secretion and sensitivity in humans.
- Subjects :
- Adiposity physiology
Adult
Blood Glucose metabolism
China
Female
Glucose Clamp Technique
Glucose Intolerance blood
Glucose Tolerance Test
Humans
Lipid Metabolism physiology
Liver Diseases blood
Liver Diseases metabolism
Male
Middle Aged
Fibroblast Growth Factors blood
Insulin Resistance physiology
Lipids blood
gamma-Glutamyltransferase blood
Subjects
Details
- Language :
- English
- ISSN :
- 1945-7197
- Volume :
- 94
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The Journal of clinical endocrinology and metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 19318452
- Full Text :
- https://doi.org/10.1210/jc.2008-2331