Back to Search
Start Over
Common variants at ten loci modulate the QT interval duration in the QTSCD Study.
- Source :
-
Nature genetics [Nat Genet] 2009 Apr; Vol. 41 (4), pp. 407-14. Date of Electronic Publication: 2009 Mar 22. - Publication Year :
- 2009
-
Abstract
- The QT interval, a measure of cardiac repolarization, predisposes to ventricular arrhythmias and sudden cardiac death (SCD) when prolonged or shortened. A common variant in NOS1AP is known to influence repolarization. We analyze genome-wide data from five population-based cohorts (ARIC, KORA, SardiNIA, GenNOVA and HNR) with a total of 15,842 individuals of European ancestry, to confirm the NOS1AP association and identify nine additional loci at P < 5 x 10(-8). Four loci map near the monogenic long-QT syndrome genes KCNQ1, KCNH2, SCN5A and KCNJ2. Two other loci include ATP1B1 and PLN, genes with established electrophysiological function, whereas three map to RNF207, near LITAF and within NDRG4-GINS3-SETD6-CNOT1, respectively, all of which have not previously been implicated in cardiac electrophysiology. These results, together with an accompanying paper from the QTGEN consortium, identify new candidate genes for ventricular arrhythmias and SCD.
- Subjects :
- Chromosome Mapping
ERG1 Potassium Channel
Electrocardiography
Electrophysiology methods
Ether-A-Go-Go Potassium Channels genetics
Heart physiology
Heart physiopathology
Humans
KCNQ1 Potassium Channel genetics
Muscle Proteins genetics
NAV1.5 Voltage-Gated Sodium Channel
Potassium Channels, Inwardly Rectifying genetics
Reproducibility of Results
Sodium Channels genetics
Arrhythmias, Cardiac genetics
Genetic Variation
Ion Channels genetics
Long QT Syndrome genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1546-1718
- Volume :
- 41
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Nature genetics
- Publication Type :
- Academic Journal
- Accession number :
- 19305409
- Full Text :
- https://doi.org/10.1038/ng.362