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Influence of Trp64Arg polymorphism of beta 3-adrenoreceptor gene on insulin resistance, adipocytokines and weight loss secondary to two hypocaloric diets.
- Source :
-
Annals of nutrition & metabolism [Ann Nutr Metab] 2009; Vol. 54 (2), pp. 104-10. Date of Electronic Publication: 2009 Mar 19. - Publication Year :
- 2009
-
Abstract
- Objective: To investigate the influence of the Trp64Arg polymorphism in the beta 3-adrenoreceptor gene on adipocytokines, insulin resistance and weight loss secondary to a low fat versus a low carbohydrate diet.<br />Methods: A population of 193 obese patients was analyzed. A nutritional evaluation was performed at the beginning and at the end of a 2-month period in which subjects received 1 of 2 hypocaloric diets.<br />Results: 172 (89.1%; 44 males, 128 females) subjects had the genotype Trp64/Trp64 (wild-type group) and 21 subjects (10.9%; 4 males, 17 females) had Trp64/Arg64 (mutant-type group). In the wild-type group BMI, weight, fat mass, waist circumference, systolic blood pressure, glucose, triglycerides, insulin, homeostasis model assessment (HOMA) and leptin decreased significantly regardless of the diet. In the mutant-type group, this was the case for BMI, weight, waist circumference, fat mass and leptin levels. Only leptin levels have a significant decrease in the wild-type group (diet I 13.7%, diet II 26.3%, p < 0.05 for both). In the mutant group, leptin decreased as well (diet I 22.5%, diet II 30.1%, p < 0.05 for both).<br />Conclusion: The metabolic effect of mild weight reduction by 2 hypocaloric diets is greatest in subjects homozygous for the normal beta 3-adrenoreceptor gene. Improvement in glucose, insulin and HOMA is better than in the mutant-type group.<br /> (2009 S. Karger AG, Basel.)
- Subjects :
- Anthropometry
Calorimetry, Indirect
Diet, Carbohydrate-Restricted
Diet, Fat-Restricted
Diet, Reducing
Female
Genotype
Humans
Insulin blood
Leptin blood
Male
Middle Aged
Mutation
Obesity blood
Prospective Studies
Resistin blood
Weight Loss genetics
Adipokines blood
Insulin Resistance genetics
Obesity diet therapy
Obesity genetics
Polymorphism, Genetic
Receptors, Adrenergic, beta-3 genetics
Weight Loss physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1421-9697
- Volume :
- 54
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Annals of nutrition & metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 19295193
- Full Text :
- https://doi.org/10.1159/000209268