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For whom the bell tolls? DING proteins in health and disease.
- Source :
-
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2009 Jul; Vol. 66 (14), pp. 2205-18. Date of Electronic Publication: 2009 Mar 17. - Publication Year :
- 2009
-
Abstract
- DING proteins, identified mainly by their eponymous N-terminal sequences, are ubiquitous in living organisms. Amongst bacteria, they are common in pseudomonads, and have been characterised with respect to genetics and structure. They form part of a wider family of phosphate-binding proteins, with emerging roles in phosphate acquisition and pathogenicity. Many DING proteins have been isolated in eukaryotes, in which they have been associated with very diverse biological activities, often in the context of possible signalling roles. Disease states in which DING proteins have been implicated include rheumatoid arthritis, lithiasis, atherosclerosis, some tumours and tumour-associated cachexia, and bacterial and viral adherence. Complete genetic and structural characterisation of eukaryotic DING genes and proteins is still lacking, though the phosphate-binding site seems to be conserved. Whether as bacterial proteins related to bacterial pathogenicity, or as eukaryotic components of biochemical signalling systems, DING proteins require further study.
- Subjects :
- Animals
Forecasting
Humans
Models, Molecular
Polycomb Repressive Complex 1
Protein Binding genetics
Protein Structure, Tertiary genetics
Structure-Activity Relationship
DNA-Binding Proteins chemistry
DNA-Binding Proteins genetics
DNA-Binding Proteins metabolism
Disease
Escherichia coli Proteins chemistry
Escherichia coli Proteins genetics
Escherichia coli Proteins metabolism
Health
Repressor Proteins chemistry
Repressor Proteins genetics
Repressor Proteins metabolism
Ubiquitin-Protein Ligases chemistry
Ubiquitin-Protein Ligases genetics
Ubiquitin-Protein Ligases metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1420-9071
- Volume :
- 66
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Cellular and molecular life sciences : CMLS
- Publication Type :
- Academic Journal
- Accession number :
- 19290474
- Full Text :
- https://doi.org/10.1007/s00018-009-0006-6