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Effect of experimental diabetes on the development and maintenance of vulvovaginal candidiasis in female rats.
- Source :
-
American journal of obstetrics and gynecology [Am J Obstet Gynecol] 2009 Jun; Vol. 200 (6), pp. 659.e1-4. Date of Electronic Publication: 2009 Mar 16. - Publication Year :
- 2009
-
Abstract
- Objective: The purpose of this study was to develop an experimental model of diabetes in female rats and verify its influence on vulvovaginal candidiasis.<br />Study Design: The animals were divided into control and diabetic groups. Diabetes was induced with the use of an intravenous solution of alloxan (42 mg/kg bodyweight). One week after confirmation of hyperglycemia, the inoculation of Candida albicans yeast, previously standardized from a vaginal isolate, in concentrations of about 5 x 10(8), was performed. Infection control was made through vaginal culture, Papanicolaou cytology, and scanning electron microscopy (SCEM).<br />Results: The results pointed to different glycemias between the control (74.8 +/- 2.6) and experimental groups (543.1 +/- 12.1) and a significant bodyweight decrease (227.6 +/- 4.77 and 204 +/- 6.39, respectively). The positive infection was shown by culture, Papanicolaou test, and SCEM in the experimental group.<br />Conclusion: Diabetes mellitus causes hyperglycemia, which was favorable to the vaginal colonization and infection by C albicans.
Details
- Language :
- English
- ISSN :
- 1097-6868
- Volume :
- 200
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- American journal of obstetrics and gynecology
- Publication Type :
- Academic Journal
- Accession number :
- 19286145
- Full Text :
- https://doi.org/10.1016/j.ajog.2009.01.011