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Replication studies for the association of PSMA6 polymorphism with coronary artery disease in East Asian populations.
- Source :
-
Journal of human genetics [J Hum Genet] 2009 Apr; Vol. 54 (4), pp. 248-51. Date of Electronic Publication: 2009 Mar 13. - Publication Year :
- 2009
-
Abstract
- Coronary artery disease (CAD) has become a major health problem in many countries because of its increasing prevalence and high mortality. Recently, an association of a functional sequence variation, -8C>G, in the human proteasome subunit alpha type 6 gene (PSMA6) with the susceptibility to CAD was reported. To validate the association, we investigated a total of 1330 cases and 2554 controls from Japanese and Korean populations for PSMA6 genotypes, and no evidence of the association was obtained in both Japanese (odds ratio (OR)=1.03, 95% confidence interval (CI); 0.90-1.19, P=0.66, allele count model) and Korean populations (OR=1.00, 95% CI; 0.86-1.17, P=0.95, allele count model). However, when a meta-analysis of data from this study and previously reported six replication studies was done, OR was 1.08 for the G allele (95% CI; 1.02-1.14, P=0.0057), suggesting that the contribution of PSMA6 to CAD was not large enough to be readily replicated. Further studies are required to establish the contribution of this variant in the susceptibility to CAD.
- Subjects :
- Alleles
Case-Control Studies
Female
Humans
Japan
Korea
Male
Meta-Analysis as Topic
Middle Aged
Odds Ratio
Reproducibility of Results
Asian People genetics
Coronary Artery Disease genetics
Genetic Predisposition to Disease
Polymorphism, Single Nucleotide genetics
Proteasome Endopeptidase Complex genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1435-232X
- Volume :
- 54
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of human genetics
- Publication Type :
- Academic Journal
- Accession number :
- 19282875
- Full Text :
- https://doi.org/10.1038/jhg.2009.22