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Folic acid and risk of prostate cancer: results from a randomized clinical trial.
- Source :
-
Journal of the National Cancer Institute [J Natl Cancer Inst] 2009 Mar 18; Vol. 101 (6), pp. 432-5. Date of Electronic Publication: 2009 Mar 10. - Publication Year :
- 2009
-
Abstract
- Data regarding the association between folate status and risk of prostate cancer are sparse and conflicting. We studied prostate cancer occurrence in the Aspirin/Folate Polyp Prevention Study, a placebo-controlled randomized trial of aspirin and folic acid supplementation for the chemoprevention of colorectal adenomas conducted between July 6, 1994, and December 31, 2006. Participants were followed for up to 10.8 (median = 7.0, interquartile range = 6.0-7.8) years and asked periodically to report all illnesses and hospitalizations. Aspirin alone had no statistically significant effect on prostate cancer incidence, but there were marked differences according to folic acid treatment. Among the 643 men who were randomly assigned to placebo or supplementation with folic acid, the estimated probability of being diagnosed with prostate cancer over a 10-year period was 9.7% (95% confidence interval [CI] = 6.5% to 14.5%) in the folic acid group and 3.3% (95% CI = 1.7% to 6.4%) in the placebo group (age-adjusted hazard ratio = 2.63, 95% CI = 1.23 to 5.65, Wald test P = .01). In contrast, baseline dietary folate intake and plasma folate in nonmultivitamin users were inversely associated with risk of prostate cancer, although these associations did not attain statistical significance in adjusted analyses. These findings highlight the potential complex role of folate in prostate cancer and the possibly different effects of folic acid-containing supplements vs natural sources of folate.
- Subjects :
- Adenoma prevention & control
Aged
Aged, 80 and over
Cyclooxygenase Inhibitors therapeutic use
Double-Blind Method
Folic Acid blood
Follow-Up Studies
Humans
Incidence
Kaplan-Meier Estimate
Male
Middle Aged
Proportional Hazards Models
Prostatic Neoplasms chemically induced
Prostatic Neoplasms mortality
Prostatic Neoplasms prevention & control
Research Design
Surveys and Questionnaires
United States epidemiology
Vitamin B Complex blood
Anti-Inflammatory Agents, Non-Steroidal therapeutic use
Aspirin therapeutic use
Colorectal Neoplasms prevention & control
Dietary Supplements
Folic Acid therapeutic use
Prostatic Neoplasms epidemiology
Vitamin B Complex therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2105
- Volume :
- 101
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of the National Cancer Institute
- Publication Type :
- Academic Journal
- Accession number :
- 19276452
- Full Text :
- https://doi.org/10.1093/jnci/djp019