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Provision of a voluntary exercise environment enhances running activity and prevents obesity in Snark-deficient mice.
- Source :
-
American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2009 May; Vol. 296 (5), pp. E1013-21. Date of Electronic Publication: 2009 Mar 10. - Publication Year :
- 2009
-
Abstract
- The present study was performed to investigate the involvement of SNARK in physical activity levels in mice. To examine the acute effect of SNARK deficiency on voluntary running, Snark-deficient mice (Snark(+/-): n = 16) and their wild-type counterparts (Snark(+/+): n = 16) were assigned to sedentary or exercise (1 wk voluntary wheel running) groups. In addition, to clarify the differences in voluntary running activity and its effect between genotypes, mice (Snark(+/+): n = 16; Snark(+/-): n = 16) were also kept in individual cages with/without a running wheel for 5 mo. Unexpectedly, in both voluntary running experiments, running distances were increased in Snark(+/-) mice compared with Snark(+/+) mice. Under sedentary conditions, body and white adipose tissue weights were increased significantly in Snark(+/-) mice. However, no significant differences were observed between the two genotypes under exercise conditions, and the values were significantly less than those under sedentary conditions in the long-term experiment. In the short-term experiment, serum interleukin-6 level in exercised Snark(+/+) mice was the same as that in sedentary Snark(+/+) mice, whereas that in sedentary Snark(+/-) mice was significantly lower than in the other groups. In contrast, serum leptin level was reduced significantly in exercised Snark(+/-) mice compared with sedentary Snark(+/-) mice. The results of this study demonstrated that exposure to an environment that allows voluntary exercise promotes increased running activity and prevents obesity in Snark-deficient mice.
- Subjects :
- Adenylate Kinase metabolism
Animals
Body Temperature physiology
Body Weight physiology
Eating physiology
Female
Glycogen metabolism
Histocytochemistry veterinary
Interleukin-6 blood
Leptin blood
Male
Mice
Mice, Knockout
Obesity blood
Obesity prevention & control
Organ Size physiology
Protein Serine-Threonine Kinases metabolism
Adenylate Kinase deficiency
Obesity enzymology
Physical Conditioning, Animal physiology
Protein Serine-Threonine Kinases deficiency
Running physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0193-1849
- Volume :
- 296
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- American journal of physiology. Endocrinology and metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 19276392
- Full Text :
- https://doi.org/10.1152/ajpendo.90891.2008