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Effect of gentamicin on vestibular ganglion.
- Source :
-
Acta oto-laryngologica. Supplementum [Acta Otolaryngol Suppl] 1991; Vol. 481, pp. 135-8. - Publication Year :
- 1991
-
Abstract
- The morphological changes of the vestibular ganglion induced by gentamicin (GM) were investigated using light, scanning and transmission electron microscopy. The guinea pigs were injected 4 mg of GM into the middle ear for 5 days. The vestibular ganglion was observed up to 4 weeks after the treatment. Three days after the treatment the degenerative change was first noted in the vestibular ganglion. The degenerative process started from the destruction of mitochondrial cristae and vacuolization of the cytoplasm of the Schwann cell. The cytoplasmic organelles in the ganglion cell gradually deteriorated with swelling of the endoplasmic cisterns as well as Golgi apparatus. At the later stage, the myelin sheath around the ganglion cell disappeared and the number of the cells reduced. These changes of the ganglion cell may be due to the direct action of GM.
- Subjects :
- Animals
Cytoplasm drug effects
Cytoplasm ultrastructure
Endoplasmic Reticulum drug effects
Endoplasmic Reticulum ultrastructure
Ganglia pathology
Guinea Pigs
Microscopy, Electron
Microscopy, Electron, Scanning
Myelin Sheath drug effects
Myelin Sheath ultrastructure
Schwann Cells drug effects
Schwann Cells ultrastructure
Vestibule, Labyrinth pathology
Ganglia drug effects
Gentamicins toxicity
Vestibule, Labyrinth drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0365-5237
- Volume :
- 481
- Database :
- MEDLINE
- Journal :
- Acta oto-laryngologica. Supplementum
- Publication Type :
- Academic Journal
- Accession number :
- 1927365
- Full Text :
- https://doi.org/10.3109/00016489109131365