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[Therapy of non-steroidal antirheumatic drug-induced gastrointestinal lesions with misoprostol].
- Source :
-
Zeitschrift fur Rheumatologie [Z Rheumatol] 1991 May-Jun; Vol. 50 (3), pp. 175-80. - Publication Year :
- 1991
-
Abstract
- In a multicenter placebo-controlled double-blind study in patients with degenerative or inflammatory rheumatic diseases the prostaglandin analogue misoprostol, in a dose of 200 micrograms twice daily after meals, was administered for the treatment of NSAID-induced lesions and symptoms of the upper gastrointestinal tract. Treatment with an NSAID was continued. Misoprostol treatment was demonstrated to be clearly superior to placebo in respect of reduction of gastroduodenal lesions and gastrointestinal pain. In addition, the physician's global assessment of gastrointestinal complaints was also statistically significantly better. No difference between the groups was found with respect to antirheumatic action of the NSAIDs.
- Subjects :
- Anti-Inflammatory Agents, Non-Steroidal therapeutic use
Double-Blind Method
Drug Therapy, Combination
Female
Gastritis drug therapy
Gastroscopy
Humans
Male
Middle Aged
Stomach Ulcer drug therapy
Anti-Inflammatory Agents, Non-Steroidal adverse effects
Anti-Ulcer Agents therapeutic use
Arthritis, Rheumatoid drug therapy
Gastritis chemically induced
Misoprostol therapeutic use
Osteoarthritis drug therapy
Stomach Ulcer chemically induced
Subjects
Details
- Language :
- German
- ISSN :
- 0340-1855
- Volume :
- 50
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Zeitschrift fur Rheumatologie
- Publication Type :
- Academic Journal
- Accession number :
- 1927064