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Synthesis of actin-depolymerizing compounds.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 Apr 01; Vol. 19 (7), pp. 1896-8. Date of Electronic Publication: 2009 Feb 21. - Publication Year :
- 2009
-
Abstract
- The artificial actin-depolymerizing compounds 3-6, based on aplyronine A, an actin-depolymerizing antitumor marine macrolide, were synthesized, and their actin-depolymerizing activities and cytotoxicities were evaluated.
- Subjects :
- Actins metabolism
Cell Line
HeLa Cells
Humans
Lactones chemistry
Lactones toxicity
Macrolides chemistry
Macrolides toxicity
Serine chemical synthesis
Serine chemistry
Serine toxicity
Actins antagonists & inhibitors
Lactones chemical synthesis
Macrolides chemical synthesis
Serine analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 19
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 19269172
- Full Text :
- https://doi.org/10.1016/j.bmcl.2009.02.068