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Normative data on mineralization density distribution in iliac bone biopsies of children, adolescents and young adults.

Authors :
Fratzl-Zelman N
Roschger P
Misof BM
Pfeffer S
Glorieux FH
Klaushofer K
Rauch F
Source :
Bone [Bone] 2009 Jun; Vol. 44 (6), pp. 1043-8. Date of Electronic Publication: 2009 Mar 04.
Publication Year :
2009

Abstract

Bone mineralization density distribution (BMDD) as assessed by quantitative backscattered electron imaging (qBEI) in iliac crest bone biopsies has become in the last years a powerful diagnostic tool to evaluate the effect of metabolic bone diseases and/or therapeutic interventions on the mineralization status of the bone material. However until now, normative reference data are only available for adults. The aim of the present study is to close this gap and establish normative data from children and compare them with reference BMDD data of adults. qBEI analyses were performed on bone samples from 54 individuals between 1.5 and 23 years without metabolic bone diseases, which were previously used as study population to establish normative histomorphometric standards. In the trabecular compartment, none of the BMDD parameters showed a significant correlation with age. The BMDD was shifted towards lower mineralization density (CaMean -5.6%, p<0.0001; CaPeak -5.6%, p<0.0001; CaLow +39.0% p<0.001; CaHigh -80.7%, p<0.001) and the inter-individual variation was higher compared to the adult population. The cortices appeared to be markedly less mineralized (CaMean -3.1%, p<0.0001) than cancellous bone due to higher amounts of low mineralized secondary bone. However, the cortical BMDD parameters showed a strong correlation (r=0.38 to 0.85, with p<0.001 to<0.0001) with cancellous BMDD parameters. In conclusion, this study provides evidence that BMDD parameters in growing healthy subjects are relatively constant and that these data can be used as normative references in pediatrics osteology. The larger inter-individual variability compared to adults is most likely related to alterations of the bone turnover rate during growth.

Details

Language :
English
ISSN :
1873-2763
Volume :
44
Issue :
6
Database :
MEDLINE
Journal :
Bone
Publication Type :
Academic Journal
Accession number :
19268565
Full Text :
https://doi.org/10.1016/j.bone.2009.02.021