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Potential association between allergic diseases and pertussis infection in schoolchildren: results of two cross-sectional studies seven years apart.
- Source :
-
Allergologia et immunopathologia [Allergol Immunopathol (Madr)] 2009 Jan-Feb; Vol. 37 (1), pp. 21-5. - Publication Year :
- 2009
-
Abstract
- Background: In this study, we aimed to investigate the relationship between pertussis infections and allergic diseases in two cross-sectional questionnaire-based surveys carried out in 1997 and 2004. We also measured serum level of antibody to B. pertussis.<br />Material and Methods: Two cross-sectional, questionnaire-based surveys were carried out in 1997 (n = 3164) and 2004 (n = 3728). 361 cases and 465 controls were recruited from both surveys. The skin tests were performed using standardised extracts. The level of pertussis specific IgG was measured in 136 allergic and 168 non-allergic children.<br />Results: We found that allergic diseases prevalence was significantly higher in the children suffering from pertussis infections (22.3 % fi rst and 8.8 % second survey) compared to children who did not suffer from pertussis infections (6.6 % fi rst and 4.5 % second survey) (p = 0.001 and p = 0.035, respectively). Asthma prevalence was also significantly higher in children suffering from pertussis infection (37.6 % fi rst and 26.2 % second survey) compared to children who did not suffer from pertussis (7.4 % fi rst and 5.0 % second survey) (p = 0.001 and p = 0.001, respectively). However, the mean serum levels of anti-pertussis IgG were similar in allergic and non-allergic groups (p > 0.05).<br />Conclusion: Although pertussis antibody levels in atopic and non-atopic children were similar to each other, pertussis infection still seemed to have a significant effect on the development of atopic diseases.
- Subjects :
- Adolescent
Asthma epidemiology
Asthma etiology
Child
Cross-Sectional Studies
Dermatitis, Atopic epidemiology
Dermatitis, Atopic etiology
Female
Humans
Hypersensitivity epidemiology
Hypersensitivity immunology
Immunoglobulin G blood
Immunoglobulin G immunology
Male
Prevalence
Rhinitis, Allergic, Perennial epidemiology
Rhinitis, Allergic, Perennial etiology
Rhinitis, Allergic, Seasonal epidemiology
Rhinitis, Allergic, Seasonal etiology
Skin Tests
Surveys and Questionnaires
Time Factors
Turkey epidemiology
Whooping Cough epidemiology
Whooping Cough immunology
Hypersensitivity etiology
Whooping Cough complications
Subjects
Details
- Language :
- English
- ISSN :
- 0301-0546
- Volume :
- 37
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Allergologia et immunopathologia
- Publication Type :
- Academic Journal
- Accession number :
- 19268057
- Full Text :
- https://doi.org/10.1016/s0301-0546(09)70247-2