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[The action of TSG101 on HIV-1 budding and related inhibitors].
- Source :
-
Yao xue xue bao = Acta pharmaceutica Sinica [Yao Xue Xue Bao] 2008 Dec; Vol. 43 (12), pp. 1165-70. - Publication Year :
- 2008
-
Abstract
- tsg101 gene is a newly found tumor suppressor gene whose product TSG101 has many important biological functions. Recent research of TSG101 has revealed that TSG101 aids HIV-1 budding from infected cells by attaching to Gag. HIV-1 budding is arrested in the cells with mutant TSG101 or without TSG101. So TSG101 would be a useful target for anti-HIV drug design. Now there is already some research on anti-HIV agents based on TSG101 structure. In this article the structure and function of TSG101 as well as the related inhibitors were reviewed.
- Subjects :
- Anti-HIV Agents chemistry
Anti-HIV Agents pharmacology
DNA-Binding Proteins chemistry
Drug Design
Endosomal Sorting Complexes Required for Transport chemistry
HIV-1 physiology
Transcription Factors chemistry
Virus Replication
Anti-HIV Agents chemical synthesis
DNA-Binding Proteins antagonists & inhibitors
DNA-Binding Proteins metabolism
Endosomal Sorting Complexes Required for Transport antagonists & inhibitors
Endosomal Sorting Complexes Required for Transport metabolism
HIV-1 growth & development
Transcription Factors antagonists & inhibitors
Transcription Factors metabolism
gag Gene Products, Human Immunodeficiency Virus metabolism
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0513-4870
- Volume :
- 43
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Yao xue xue bao = Acta pharmaceutica Sinica
- Publication Type :
- Academic Journal
- Accession number :
- 19244744