Cytomorphological study of the development of fibrotic complications in chronic SiO(2) granulomatosis in the liver during radon treatment.

Granulomatosis was induced in male Wistar rats by intravenous injection of SiO(2). The course of SiO(2) granulomatosis was cyclic in animals receiving radon baths: phase 1 was characterized by an increase in the number and size of granulomas, while during phase 2 the intensity of the inflammatory process decreased and fibrosing of granulomas progressed. No trends to alleviation of the inflammatory process were noted in rats with SiO(2) granulocytosis receiving tap water baths.