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[Non-developing pregnancy: histological and immunohistochemical markers of endocrine disorders in endometrial scrapes].
- Source :
-
Arkhiv patologii [Arkh Patol] 2008 Nov-Dec; Vol. 70 (6), pp. 22-5. - Publication Year :
- 2008
-
Abstract
- Histological and immunohistological (monoclonal antibodies against desmin, vimentin, glycodelin, IGFBP-1, estrogen receptors and progesterone receptors) studies were carried out to examine uterine scrapes from 47 healthy women - medical abortions from 6 to 10 weeks of conception and from 44 patients after non-developing pregnancy in the first trimester (recurrent miscarriage), which had been induced by verified endocrine disorders. Among them, three isolated pathogenetic types were identified: 1) uterine gland retardation as preserved islets of cylindrical glands with a narrow lumen or, on the contrary, areas with enlarged glands and atrophic epitheliocytes; immunohistochemically, they exhibited a drastic reduction in the expression of glycodelin, the major local immunosuppressor; 2) incomplete decidualization when it in the presence of progesterone deficiency was delayed at the state of predecidual and decidual cells retaining the smooth muscle cell marker - desmin; 3) verified progesterone receptor insufficiency. Each of the given clinical and morphological types of endocrine causes of non-developing pregnancy requires that an individual approach be applied to examining and treating these patients.
- Subjects :
- Abortion, Missed etiology
Adult
Biomarkers metabolism
Desmin metabolism
Endocrine System Diseases complications
Endometrium metabolism
Female
Humans
Immunohistochemistry
Insulin-Like Growth Factor Binding Protein 1 metabolism
Pregnancy
Pregnancy Trimester, First metabolism
Vimentin metabolism
Abortion, Missed metabolism
Abortion, Missed pathology
Endocrine System Diseases metabolism
Endocrine System Diseases pathology
Endometrium pathology
Subjects
Details
- Language :
- Russian
- ISSN :
- 0004-1955
- Volume :
- 70
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Arkhiv patologii
- Publication Type :
- Academic Journal
- Accession number :
- 19227277