Effects of the introduction of inversion of polarity sites in the quadruplex forming oligonucleotide TGGGT.

Authors :: Esposito V
Virgilio A
Pepe A
Oliviero G
Mayol L
Galeone A
Source :: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2009 Mar 01; Vol. 17 (5), pp. 1997-2001. Date of Electronic Publication: 2009 Jan 20.
Publication Year :: 2009
Abstract: Insight into the influence of inversion of polarity sites on the structural features of quadruplex structures is presented. The NMR and CD studies concern modified oligodeoxynucleotides (ODNs) based on the quadruplex forming sequence TGGGT. The presence of inversion of polarity sites not only does not compromise the formation of quadruplexes, but in some cases it increases the thermal stability of modified complexes compared with that of the unmodified one.

Subjects :: Base Sequence
Circular Dichroism
Magnetic Resonance Spectroscopy
Nucleic Acid Conformation
Transition Temperature
G-Quadruplexes
Glycosides chemistry
Oligodeoxyribonucleotides chemistry

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