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Controlled release of matrix metalloproteinase 1 with or without skeletal myoblasts transplantation improves cardiac function of rat hearts with chronic myocardial infarction.
- Source :
-
Tissue engineering. Part A [Tissue Eng Part A] 2009 Sep; Vol. 15 (9), pp. 2699-706. - Publication Year :
- 2009
-
Abstract
- Skeletal myoblast transplantation has been applied clinically for severe ischemic cardiomyopathy. Matrix metalloproteinase 1 (MMP-1) reduces fibrosis and prevents the progress of heart failure. We hypothesized that MMP-1 administration to the infarct area enhances the efficacy of skeletal myoblast transplantation. The controlled release of MMP-1 improved cardiac functions of rats with chronic myocardiac infarction with or without transplantation of skeletal myoblasts. Improvement in cardiac function and small fibrotic area inside the infarcted area were observed compared with those of myoblast transplantation. In conclusion, controlled release of MMP-1 was effective in cardioprotection in postmyocardial infarction although the combination with cell transplantation showed the similar effect.
- Subjects :
- Animals
Cardiac Catheterization
Chronic Disease
DNA administration & dosage
Delayed-Action Preparations
Fibrosis
Fluorescent Antibody Technique
Humans
Myocardial Infarction diagnostic imaging
Myocardial Infarction pathology
Myocardium pathology
Organ Size
Plasmids administration & dosage
Rats
Rats, Inbred Lew
Tissue Donors
Ultrasonography
Heart Function Tests
Matrix Metalloproteinase 1 administration & dosage
Myoblasts, Skeletal transplantation
Myocardial Infarction physiopathology
Myocardial Infarction therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1937-335X
- Volume :
- 15
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Tissue engineering. Part A
- Publication Type :
- Academic Journal
- Accession number :
- 19216640
- Full Text :
- https://doi.org/10.1089/ten.TEA.2008.0637