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The safety of olanzapine in adolescents with schizophrenia or bipolar I disorder: a pooled analysis of 4 clinical trials.
- Source :
-
The Journal of clinical psychiatry [J Clin Psychiatry] 2009 Feb; Vol. 70 (2), pp. 247-58. Date of Electronic Publication: 2009 Feb 10. - Publication Year :
- 2009
-
Abstract
- Objective: To describe the safety of olanzapine treatment in adolescents (aged 13-17 years) with schizophrenia or bipolar I disorder, and to compare these data with those of olanzapine-treated adults.<br />Data Sources and Study Selection: Placebo-controlled database, adolescents: acute phase of 2 double-blind, placebo-controlled trials (3-6 weeks; olanzapine, N = 179, mean age = 15.5 years; placebo, N = 89, mean age = 15.7 years); overall adolescent olanzapine exposure database, adolescents: 4 trials (e.g., the 2 aforementioned studies, each with a 26-week open-label extension phase, and 2 open-label, 4.5- and 24-week trials; N = 454, mean age = 15.9 years); and adult database: 84 clinical trials of up to 32 weeks.<br />Data Synthesis: The mean daily dosage of olanzapine was 10.6 mg/day (exposure = 48,946 patient days). In the overall adolescent olanzapine exposure database, the most common adverse events included increased weight (31.7%), somnolence (19.8%), and increased appetite (17.4%). In up to 32 weeks of treatment, when compared with adults, adolescents from the overall adolescent olanzapine exposure database gained statistically significantly more weight (7.4 kg vs. 3.2 kg, p < .001); statistically significantly more adolescents gained > or = 7% of their baseline weight (65.1% vs. 35.6%, p < .001). Adolescents experienced statistically significant within-group baseline-to-endpoint changes in fasting glucose (p < .001), total cholesterol (p = .002), triglycerides (p = .007), and alanine aminotransferase (p < .001). Two patients from the overall adolescent olanzapine exposure database (0.4%) attempted suicide; 13 (2.9%) had suicidal ideation. In the placebo-controlled database, adolescents had statistically significant baseline-to-endpoint increases in prolactin (11.4 micrograms/L, p < .001); 47.4% had high prolactin levels.<br />Conclusions: The types of adverse events in olanzapine-treated adolescents appear to be similar to those of adults. The magnitude and incidence of weight and prolactin changes were greater in adolescents.<br />Trial Registration: clinicaltrials.gov Identifiers: NCT00051298, NCT00050206, and NCT00113594.<br /> (Copyright 2009 Physicians Postgraduate Press, Inc.)
- Subjects :
- Adolescent
Adult
Adverse Drug Reaction Reporting Systems
Age Factors
Antipsychotic Agents therapeutic use
Benzodiazepines therapeutic use
Bipolar Disorder diagnosis
Dose-Response Relationship, Drug
Double-Blind Method
Drug-Related Side Effects and Adverse Reactions
Female
Humans
Male
Meta-Analysis as Topic
Olanzapine
Randomized Controlled Trials as Topic statistics & numerical data
Schizophrenia diagnosis
Antipsychotic Agents adverse effects
Benzodiazepines adverse effects
Bipolar Disorder drug therapy
Schizophrenia drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1555-2101
- Volume :
- 70
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Journal of clinical psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 19210948
- Full Text :
- https://doi.org/10.4088/jcp.08m03538