3D-CT volumetry of the lung using multidetector row CT: comparison with pulmonary function tests.

Rationale and Objectives: The aim of this study was to evaluate the accuracy of measurements of lung volumes reconstructed using three-dimensional computed tomographic (CT) imaging from thin-section multidetector-row CT images compared to standard pulmonary function testing.
Materials and Methods: Preoperative three-dimensional CT images and pulmonary function test results of 64 patients with solitary pulmonary nodules who were considered candidates for lung resection were reviewed. On the three-dimensional CT images, total lung capacity (TLC(CTV)), emphysematous lung capacity (ELC(CTV)), and normal lung capacity (NLC(CTV)) were calculated. Total lung capacity (TLC), vital capacity, and forced expiratory volume in 1 second were measured using spirometry.
Results: There was a strong positive correlation between estimated TLC(CTV) and measured TLC values (r = 0.87, P < .001). Estimated ELC(CTV) at the threshold value of -900 Hounsfield units was negatively correlated with forced expiratory volume in 1 second (r = -0.56, P < .001). NLC(CTV) values were more strongly correlated with vital capacity values than TLC(CTV) values (r = 0.74, P < .001).
Conclusions: Lung volume calculated using three-dimensional CT volumetry was well correlated with lung volume measured using spirometry. Three-dimensional CT volumetry can be used to evaluate pulmonary function.