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A comparison of urinary neutrophil gelatinase-associated lipocalin in patients undergoing on- versus off-pump coronary artery bypass graft surgery.
- Source :
-
Journal of cardiothoracic and vascular anesthesia [J Cardiothorac Vasc Anesth] 2009 Apr; Vol. 23 (2), pp. 195-9. Date of Electronic Publication: 2009 Feb 07. - Publication Year :
- 2009
-
Abstract
- Objective: The purpose of this study was to compare urinary neutrophil gelatinase-associated lipocalin (NGAL) levels in off-pump and on-pump coronary artery bypass graft (CABG) surgery.<br />Design: A matched cohort study.<br />Setting: A tertiary university hospital.<br />Participants: Thirty adult patients undergoing CABG surgery without cardiopulmonary bypass (off-pump) matched to 30 patients with on-pump CABG surgery by age, preoperative serum creatinine, Parsonnet score, ejection fraction, body mass index, and number of coronary artery grafts.<br />Interventions: None, observational.<br />Measurements and Main Results: Urinary NGAL, a novel, highly sensitive biomarker for renal injury, was measured before and immediately after surgery and then 3, 18, and 24 hours later. There were no differences in urinary NGAL at any time point between patients subjected to off-pump or on-pump CABG surgery; the peak urinary NGAL in patients who underwent off-pump CABG surgery was 94.7 +/- 30.9 ng/mL compared with 122.7 +/- 57.0 ng/mL in patients with on-pump CABG surgery (p = 0.6). Peak serum creatinine and the incidence of acute kidney injury also were not different between the groups.<br />Conclusions: Urinary NGAL was not different in patients undergoing off-pump and on-pump CABG surgery despite a very good match between the groups with respect to pre- and intraoperative risk factors.
- Subjects :
- Aged
Biomarkers
Body Mass Index
Cohort Studies
Creatinine blood
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunoblotting
Kidney Function Tests
Lipocalin-2
Male
Risk Factors
Stroke Volume physiology
Acute-Phase Proteins urine
Coronary Artery Bypass
Coronary Artery Bypass, Off-Pump
Lipocalins urine
Proto-Oncogene Proteins urine
Subjects
Details
- Language :
- English
- ISSN :
- 1532-8422
- Volume :
- 23
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of cardiothoracic and vascular anesthesia
- Publication Type :
- Academic Journal
- Accession number :
- 19201208
- Full Text :
- https://doi.org/10.1053/j.jvca.2008.11.018