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Transient increase in cytokines and nerve growth factor in the rat dorsal root ganglia after nerve lesion and peripheral inflammation.
- Source :
-
Journal of neuroimmunology [J Neuroimmunol] 2009 Mar 31; Vol. 208 (1-2), pp. 94-103. Date of Electronic Publication: 2009 Feb 05. - Publication Year :
- 2009
-
Abstract
- Inflammatory response occurs, in general, at the peripheral site of injury or irritation and in the corresponding spinal dorsal horn segments. In this study, we show transient increases in the protein concentrations of interleukins 1beta, 6, 8 and NGF in lumbar DRGs within hours after sciatic mononeuropathy in the rat. Comparable increases, with variation in temporal patterns, were observed after skin inflammation induced by intraplantar injection of endotoxin or complete Freund's adjuvant. The non-matching temporal profiles of cytokines and NGF increases and those of behavioral hypersensitivity, particularly peak values, suggest that the roles of these proteins are not necessarily pro-nociceptive in the DRGs at the chronic phase of neuropathy.
- Subjects :
- Animals
Cytokines physiology
Female
Ganglia, Spinal immunology
Hyperalgesia immunology
Hyperalgesia metabolism
Hyperalgesia pathology
Inflammation immunology
Inflammation metabolism
Nerve Growth Factor physiology
Peripheral Nervous System Diseases immunology
Peripheral Nervous System Diseases metabolism
Peripheral Nervous System Diseases pathology
Rats
Rats, Sprague-Dawley
Sciatic Neuropathy immunology
Sciatic Neuropathy metabolism
Time Factors
Cytokines biosynthesis
Ganglia, Spinal metabolism
Ganglia, Spinal pathology
Nerve Growth Factor biosynthesis
Sciatic Neuropathy pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-8421
- Volume :
- 208
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Journal of neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 19200610
- Full Text :
- https://doi.org/10.1016/j.jneuroim.2009.01.011