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Novel 24-membered macrolides, JBIR-19 and -20 isolated from Metarhizium sp. fE61.
- Source :
-
The Journal of antibiotics [J Antibiot (Tokyo)] 2009 Mar; Vol. 62 (3), pp. 159-62. Date of Electronic Publication: 2009 Feb 06. - Publication Year :
- 2009
-
Abstract
- In the course of our screening program for active compounds that induce cell morphological changes of Saccharomyces cerevisiae, the culture broth of an entomopathogenic fungus Metarhizium sp. fE61 exhibited a unique morphological phenotype. We conducted an activity-guided isolation from the fermentation broth of Metarhizium sp. fE61 to yield two new macrolide compounds named JBIR-19 (1) and -20 (2) as active substances. Their structures were determined to be 24-membered macrolide analogs containing a 2-aminoethyl phosphate ester on the basis of NMR and other spectroscopic data. Compounds 1 and 2 induced striking elongated morphology of S. cerevisiae at concentrations of 3.1 and 13 microM, but showed weak antiyeast activity at MICs of 200 and >200 microM, respectively.
- Subjects :
- Antifungal Agents chemistry
Antifungal Agents pharmacology
Chromatography, High Pressure Liquid
Culture Media
Fermentation
Macrolides chemistry
Macrolides pharmacology
Magnetic Resonance Spectroscopy
Metarhizium classification
Saccharomyces cerevisiae drug effects
Spectrometry, Mass, Electrospray Ionization
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Antifungal Agents biosynthesis
Macrolides metabolism
Metarhizium metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1881-1469
- Volume :
- 62
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of antibiotics
- Publication Type :
- Academic Journal
- Accession number :
- 19198639
- Full Text :
- https://doi.org/10.1038/ja.2009.5