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UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality.
- Source :
-
Cell metabolism [Cell Metab] 2009 Feb; Vol. 9 (2), pp. 203-9. - Publication Year :
- 2009
-
Abstract
- As original studies of UCP1-ablated mice failed to demonstrate an obesogenic effect, alternative mechanisms for adaptive adrenergic thermogenesis have been sought. However, we demonstrate here that in C57Bl6 mice exempt from thermal stress (i.e., kept at thermoneutrality), UCP1 ablation in itself induced obesity, even in mice fed control diet, and vastly augmented diet-induced obesity (high-fat diet); i.e., the mice exhibited increased metabolic efficiency. In wild-type mice, high-fat diet increased norepinephrine-induced thermogenesis; i.e., diet-induced thermogenesis was observed, but no such effect was observed in UCP1-ablated mice, demonstrating that diet-induced thermogenesis fully emanates from UCP1 activity. We conclude that ambient temperature is qualitatively determinative for the outcome of metabolic studies, that no other protein and no other mechanism can substitute for UCP1 in mediating diet-induced adrenergic thermogenesis, and that UCP1 activity can be determinative for obesity development in mice and possibly in humans.
- Subjects :
- Adipose Tissue, Brown metabolism
Animals
Eating
Energy Metabolism
Humans
Ion Channels metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Mitochondrial Proteins metabolism
Norepinephrine metabolism
Receptors, Adrenergic, beta metabolism
Temperature
Uncoupling Protein 1
Ion Channels genetics
Mitochondrial Proteins genetics
Obesity etiology
Stress, Physiological
Thermogenesis
Subjects
Details
- Language :
- English
- ISSN :
- 1932-7420
- Volume :
- 9
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cell metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 19187776
- Full Text :
- https://doi.org/10.1016/j.cmet.2008.12.014