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Pilot study of new diagnostic criteria for middle cerebral artery stenosis by transcranial Doppler.
- Source :
-
Journal of neuroimaging : official journal of the American Society of Neuroimaging [J Neuroimaging] 2010 Apr; Vol. 20 (2), pp. 122-9. Date of Electronic Publication: 2009 Jan 29. - Publication Year :
- 2010
-
Abstract
- Background and Purpose: Current criteria for middle cerebral artery (MCA) stenosis by transcranial Doppler were mainly based on the flow velocity acceleration, ignoring other useful parameters. We tested the accuracy of new criteria using magnetic resonance angiography (MRA) as the confirmative method.<br />Methods: A compositive score for each MCA was calculated according to following parameters: Velocity Scale (score 0-6 for peak systolic velocity <140 to > or = 300 cm/second), Hemodynamic Scale (score 0-5 for diffuse or focal velocity increase; score 0-6 for differences between bilateral MCA; score 17 for damping velocity), and Spectrum Scale (score 0-2 for normal spectrum, turbulence, and musical murmurs).<br />Results: The median scores in normal-mild, moderate, and severe groups on MRA differed significantly (P < .001). The optimal cutoff score for <50% and > or = 50% stenosis was 3 with the PPV of 72.3% (95% confidence interval [CI]: 65.3% to 78.5%) and negative predictive value (NPV) of 89.5% (95% CI: 85.9% to 92.3%), for moderate and severe stenosis was 6 with the PPV of 85.9% (95% CI: 76.7% to 92.0%) and NPV of 61.9% (95% CI: 50.6% to 72.1%). Both scores performed better than peak systolic or mean velocity.<br />Conclusions: This new method was feasible and reliable and showed some advantages over the velocity-only method. Further studies using digital subtraction angiography as the gold standard are needed to ameliorate the new criteria.
Details
- Language :
- English
- ISSN :
- 1552-6569
- Volume :
- 20
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of neuroimaging : official journal of the American Society of Neuroimaging
- Publication Type :
- Academic Journal
- Accession number :
- 19187479
- Full Text :
- https://doi.org/10.1111/j.1552-6569.2008.00337.x