Impact of internal biliary drainage after pancreaticoduodenectomy.

Authors :: Fujino Y
Matsumoto I
Shinzeki M
Ajiki T
Kuroda Y
Source :: Journal of hepato-biliary-pancreatic surgery [J Hepatobiliary Pancreat Surg] 2009; Vol. 16 (2), pp. 160-4. Date of Electronic Publication: 2009 Jan 30.
Publication Year :: 2009
Abstract: Background: Bile acid has an important role in protecting immune systems related to gut-associated lymphoid tissue. This study was designed to evaluate the effects of internal biliary drainage after a pancreaticoduodenectomy (PD) on postoperative nutrition and complications in a randomized study.<br />Methods: The authors compared the morbidity, mortality, and postoperative nutritional status of 46 patients who had a hepaticojejunostomy (HJ) with a stented external biliary drainage (group E) or with a non-stented internal biliary drainage (group I) after a PD.<br />Results: Systemic infection was recognized in four patients in group E, while no patients in group I. Transthyretin at postoperative 28 days in group I was 15.6 +/- 6.2, higher than that in group E. Retinol-binding protein at postoperative 28 days in group I was 2.6 +/- 1.0 and also higher than that in group E.<br />Conclusion: HJ with no-stented internal biliary drainage was not associated with systemic infections and mortality, but showed the possibility of improving nutritional status.