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Reduction of collagen biosynthesis in blood vessels and other tissues by reserpine and hypophysectomy.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 1977 Feb; Vol. 74 (2), pp. 777-9. - Publication Year :
- 1977
-
Abstract
- Synthesis of collagen in the vasculature and other tissues of normotensive rats is markedly reduced by reserpine. Hypophysectomy produces similar effects. The effects of reserpine on collagen biosynthesis may be mediated through the hypothalamus.
- Subjects :
- Animals
Aorta drug effects
Growth Hormone pharmacology
Heart drug effects
Hydroxyproline urine
Lung drug effects
Lung metabolism
Male
Mesenteric Arteries drug effects
Myocardium metabolism
Organ Specificity
Procollagen-Proline Dioxygenase metabolism
Rats
Skin drug effects
Skin metabolism
Aorta metabolism
Collagen biosynthesis
Hypophysectomy
Mesenteric Arteries metabolism
Reserpine pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0027-8424
- Volume :
- 74
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 191825
- Full Text :
- https://doi.org/10.1073/pnas.74.2.777