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HLA-E gene polymorphism associated with susceptibility to Kawasaki disease and formation of coronary artery aneurysms.
- Source :
-
Arthritis and rheumatism [Arthritis Rheum] 2009 Feb; Vol. 60 (2), pp. 604-10. - Publication Year :
- 2009
-
Abstract
- Objective: Kawasaki disease (KD) is a pediatric systemic vasculitis of unknown cause for which a genetic influence is supposed. The purpose of this study was to identify possible genetic variants in the major histocompatibility complex (MHC) region that are associated with KD and the development of coronary artery aneurysms (CAAs) in a Taiwanese population.<br />Methods: The 168 genetic variants covering the MHC locus were analyzed in an association study of a Taiwanese cohort of 93 KD patients and 680 unrelated healthy children matched for sex and age with the study patients.<br />Results: Eleven single-nucleotide polymorphisms (SNPs) were associated with the occurrence of KD. The SNP located at the 3'-untranslated region of HLA-E (rs2844724) was highly associated (P < 1 x 10(-7)). In addition, the frequency of the C allele was higher in KD patients without CAAs than in controls (P < 0.001) due to a significantly increased frequency of the CC and CT genotypes. Plasma levels of soluble HLA-E were significantly higher in KD patients than in controls regardless of the presence of CAAs. Furthermore, there was a trend toward higher plasma levels of soluble HLA-E in KD patients with the CT and TT genotypes of the HLA-E gene polymorphism.<br />Conclusion: Our results suggest that the HLA-E gene polymorphism may play a role in the pathogenesis of KD.
- Subjects :
- Child
Child, Preschool
Cohort Studies
Comorbidity
Coronary Aneurysm epidemiology
Coronary Aneurysm pathology
Coronary Vessels
Female
Humans
Male
Mucocutaneous Lymph Node Syndrome epidemiology
Mucocutaneous Lymph Node Syndrome pathology
Taiwan epidemiology
HLA-E Antigens
Chromosomes, Human, Pair 6
Coronary Aneurysm genetics
Genetic Predisposition to Disease
HLA Antigens genetics
Histocompatibility Antigens Class I genetics
Mucocutaneous Lymph Node Syndrome genetics
Polymorphism, Single Nucleotide
Subjects
Details
- Language :
- English
- ISSN :
- 0004-3591
- Volume :
- 60
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Arthritis and rheumatism
- Publication Type :
- Academic Journal
- Accession number :
- 19180512
- Full Text :
- https://doi.org/10.1002/art.24261