Back to Search
Start Over
Synthesis of citrate-ciprofloxacin conjugates.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 Mar 01; Vol. 19 (5), pp. 1496-8. Date of Electronic Publication: 2009 Jan 10. - Publication Year :
- 2009
-
Abstract
- Two regioisomeric citrate-functionalized ciprofloxacin conjugates have been synthesized and their antimicrobial activities against a panel of clinically-relevant bacteria have been determined. Cellular uptake mechanisms were investigated using wild-type and ompF deletion strains of Escherichia coli K-12.
- Subjects :
- Ciprofloxacin pharmacology
Citric Acid pharmacology
Escherichia coli K12 drug effects
Escherichia coli K12 genetics
Escherichia coli K12 growth & development
Gene Deletion
Humans
Porins deficiency
Porins genetics
Pseudomonas aeruginosa drug effects
Pseudomonas aeruginosa growth & development
Staphylococcus aureus drug effects
Staphylococcus aureus growth & development
Staphylococcus epidermidis drug effects
Staphylococcus epidermidis growth & development
Ciprofloxacin chemical synthesis
Citric Acid chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 19
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 19179071
- Full Text :
- https://doi.org/10.1016/j.bmcl.2009.01.007