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Demonstration of 1-year duration of immunity for attenuated Bordetella bronchiseptica vaccines in dogs.
- Source :
-
Veterinary therapeutics : research in applied veterinary medicine [Vet Ther] 2008 Winter; Vol. 9 (4), pp. 257-62. - Publication Year :
- 2008
-
Abstract
- Three groups of healthy dogs with low antibody titers to Bordetella bronchiseptica (Bb), canine parainfluenza virus (CPI), and canine adenovirus type 2 (CAV-2) were used in this study. One group was vaccinated with a single dose of monovalent attenuated Bb vaccine and one group with a trivalent vaccine containing attenuated Bb, CPI, and CAV-2; dogs were vaccinated intranasally with a single dose of the respective vaccines. The third group served as unvaccinated controls. All vaccinated dogs subsequently developed serum antibody titers to Bb that persisted for at least 1 year. Following Bb challenge 1 year after vaccination, all vaccinated dogs, regardless of group, showed significantly fewer clinical signs and shed significantly fewer challenge organisms than unvaccinated controls. These results demonstrate that intranasal administration of a single dose of monovalent attenuated Bb vaccine or trivalent vaccine containing attenuated Bb, CPI, and CAV-2 provides 1 year of protection against Bb.
- Subjects :
- Adenoviridae Infections prevention & control
Adenoviridae Infections veterinary
Adenoviruses, Canine immunology
Administration, Intranasal
Animals
Animals, Newborn
Antibodies, Viral blood
Bordetella Infections prevention & control
Dogs
Female
Male
Parainfluenza Vaccines administration & dosage
Parainfluenza Virus 2, Human immunology
Random Allocation
Rubulavirus Infections prevention & control
Rubulavirus Infections veterinary
Vaccines, Attenuated
Antibodies, Bacterial blood
Bacterial Vaccines administration & dosage
Bordetella Infections veterinary
Bordetella bronchiseptica immunology
Dog Diseases prevention & control
Viral Vaccines administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1528-3593
- Volume :
- 9
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Veterinary therapeutics : research in applied veterinary medicine
- Publication Type :
- Academic Journal
- Accession number :
- 19177330