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Evaluation of adjuvant doxorubicin-based chemotherapy for the treatment of feline mammary carcinoma.
- Source :
-
Journal of veterinary internal medicine [J Vet Intern Med] 2009 Jan-Feb; Vol. 23 (1), pp. 123-9. - Publication Year :
- 2009
-
Abstract
- Background: Feline mammary carcinomas (FMC) are locally invasive and highly metastatic tumors. Because of the high metastatic potential, patients often are treated with adjuvant doxorubicin-based chemotherapy, but little data exist to evaluate the effect of this strategy.<br />Hypothesis: Adjuvant doxorubicin-based chemotherapy improves outcome for FMC compared with surgery alone.<br />Animals: Cats with naturally occurring, biopsy-confirmed FMC treated with either surgery alone (Sx) or with surgery plus adjuvant doxorubicin-based chemotherapy (Sx + Chemo).<br />Methods: Retrospective cohort study. Clinical data were collected and compared to identify differences between groups. Outcome results were determined and compared. Prognostic factors for disease-free survival (DFS) and overall survival were evaluated.<br />Results: Seventy-three cats were evaluated, of which 37 were in the Sx group and 36 in the Sx + Chemo group. No differences in clinical data were found between Sx and Sx + Chemo groups. Median DFS times for the Sx and Sx + Chemo groups were 372 and 676 days, respectively (P= .15) and median survival times (ST) were 1,406 and 848 days, respectively (P= .78). For cats that underwent a unilateral radical mastectomy, ST was significantly longer for the Sx + Chemo compared with the Sx group (1,998 versus 414 days, respectively; P= .03).<br />Conclusions and Clinical Importance: This study did not find a benefit to adjuvant doxorubicin-based chemotherapy in cats with FMC. Additional studies are required to determine whether patient subgroups with negative prognostic factors may benefit from adjuvant chemotherapy.
- Subjects :
- Animals
Cat Diseases surgery
Cats
Chemotherapy, Adjuvant
Cohort Studies
Cyclophosphamide administration & dosage
Cyclophosphamide therapeutic use
Female
Male
Mammary Neoplasms, Animal surgery
Retrospective Studies
Antineoplastic Agents administration & dosage
Antineoplastic Agents therapeutic use
Cat Diseases drug therapy
Doxorubicin administration & dosage
Doxorubicin therapeutic use
Mammary Neoplasms, Animal drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0891-6640
- Volume :
- 23
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of veterinary internal medicine
- Publication Type :
- Academic Journal
- Accession number :
- 19175730
- Full Text :
- https://doi.org/10.1111/j.1939-1676.2008.0244.x