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[Interaction between an insertion/deletion polymorphism in pepsinogen C and Helicobacter pylori infection in the development of gastric cancer].
- Source :
-
Zhonghua zhong liu za zhi [Chinese journal of oncology] [Zhonghua Zhong Liu Za Zhi] 2008 Sep; Vol. 30 (9), pp. 644-8. - Publication Year :
- 2008
-
Abstract
- Objective: This study was designed to investigate the interaction between pepsinogen C(PGC) insertion/deletion polymorphism and Helicobacter pylori(Hp) infection, together with its different subtype strains, in the development of gastric cancer (GC).<br />Methods: PGC Genotypes were determined by polymerase chain reaction (PCR) assay in 564 subjects with superficial gastritis (NOR), gastric ulcer (GU), atrophic gastritis (AG) and GC, who were frequency-matched as 1:1. Serum Hp-IgG antibodies were determined by an enzyme linked immunoadsorbent assay (ELISA). Hp genetic subtypes in 171 patients with Hp infection were determined by PCR methods.<br />Results: In GU, AG and GC, the OR of interaction was 8.69 (P = 0.049), 11.16 (P = 0.02), and 10.61 (P = 0.03), respectively; the interaction index of PGC homozygous allele 1 genotype and Hp infection was 5.40, 6.48 or 4.34, respectively; the attributable proportions were 0.721, 0.770 and 0.697, respectively. In AG and GC, no significant interactions were observed between PGC polymorphism and Hp genetic subtypes.<br />Conclusion: The findings of this study suggest that PGC insertion/deletion polymorphism and Hp infection seem to present a positive interaction in the development of gastric cancer. While no interactions may be present between PGC polymorphism and Hp genetic subtypes.
- Subjects :
- Adult
Aged
Aged, 80 and over
Alleles
Base Sequence
Female
Gastritis genetics
Gastritis, Atrophic genetics
Genotype
Helicobacter pylori pathogenicity
Humans
Male
Middle Aged
Molecular Sequence Data
Stomach Neoplasms microbiology
Stomach Ulcer genetics
Young Adult
Genetic Predisposition to Disease genetics
Helicobacter Infections genetics
INDEL Mutation
Pepsinogen C genetics
Polymorphism, Genetic
Stomach Neoplasms genetics
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0253-3766
- Volume :
- 30
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Zhonghua zhong liu za zhi [Chinese journal of oncology]
- Publication Type :
- Academic Journal
- Accession number :
- 19173902